Hyaluronic dermal fillers and Botox remain the two most important and effective tools in aesthetic medicine - and if we're talking about aesthetics in general, they have now become even more popular than the most common surgical procedures such as rhinoplasty, facelifting, liposuction, or breast augmentation.
In 2025, modern aesthetic medicine offers a vast array of lasers and devices designed to rejuvenate the skin and tighten the face, and in recent years we've witnessed an incredible boom in new skin biostimulators. The selection has become outstanding - allowing us to combine treatments to achieve remarkably effective and natural-looking results.
Although Botox is still the best solution for smoothing wrinkles, and hyaluronic fillers are unmatched in restoring volume to hollow cheeks, deep lines, or under-eye areas, combining them with biostimulators gives the skin a beautiful, luminous glow and enhances overall results.
Biostimulators offer facial and skin rejuvenation for those who prefer to avoid Botox or dermal fillers. The skin, as the body's largest organ, is constantly exposed to external and internal stressors. While both Botox and fillers stimulate collagen and elastin production to some degree, the new generation of biostimulators does it even better. The options available now - two decades later - are truly remarkable. Every month brings new innovations, and every major aesthetic congress introduces something that raises the bar for non-surgical facial and body rejuvenation.
In short, biostimulation encourages the skin to produce its own collagen, elastin, and hyaluronic acid, resulting in firmer, healthier, more radiant, and more elastic skin. These new-generation products work by stimulating fibroblasts - the skin's active cells responsible for collagen, elastin, and hyaluronic acid synthesis (the extracellular matrix).
Collagen is the key to firm skin and one of the most abundant proteins in the human body, making up about 75% of the skin's structure. It maintains firmness and shape, with Type I and Type III collagen being the most dominant. Type I provides structural support, while Type III aids in repair and regeneration. Unfortunately, collagen levels decline rapidly with age - adults lose about 1% per year. By age 35, up to 15% is gone; by 45, around 25%; and by 55, as much as 35%.
In an era when patients increasingly seek natural-looking results, the combination of laser and injectable rejuvenation treatments offers personalized solutions tailored to each patient's skin and desires. Biostimulators can be used alongside Botox and fillers or as standalone treatments.
They make the skin look healthy, youthful, and radiant - something aesthetic surgery alone cannot achieve. But with so many options available, choosing the right one can be overwhelming. Which treatment to pick? Which are the best biostimulators?
To make your choice easier, I've compiled a list of the top biostimulators on the market - starting with those I've used the longest at Milojević Clinic and moving to some of the exciting new "kids on the block."
Top 10 Biostimulators
- Skinboosters
Products like Restylane Vitaland Juvederm Volite have been around for over 15 years. Leading companies such as Merz, Teoxane, Neuvia, and Fillmed have developed their own versions. They contain stabilized hyaluronic acid, like dermal fillers, but in lower concentrations. Instead of being injected deeply, they're applied via mesotherapy - through multiple microinjections across the skin or with a cannula. - Sculptra
I attended the first Sculptra training back in 2008. It's the original and iconic collagen biostimulator containing Poly-L-Lactic Acid (PLLA) - a fully resorbable polymer that works in the deeper layers of the skin to improve its internal structure. Newer PLLA and PDLA alternatives include Lanluma, Aespella, and Juvelook. - PRP (PRGF)
I've used platelet-rich plasma therapy for over 12 years - also known by its nickname, the "vampire facial." Blood is drawn from the patient and centrifuged to extract plasma rich in growth factors and stem cells. I'm proud to say that 100% of our patients have been satisfied with their PRP results. - Profhilo
Only the fourth on the list, yet one of the newer anti-aging marvels. Profhilo rejuvenates the skin through a mechanism called bioremodelling - a blend of high- and low-molecular-weight hyaluronic acid. Unlike dermal fillers, it isn't stabilized, remains in the skin for weeks rather than months, and doesn’t add facial volume. It’s one of the world’s most sought-after and award-winning biostimulation treatments. - Sunekos
A biostimulator similar to Profhilo, yet distinct in composition - combining non-crosslinked hyaluronic acid with six precisely balanced amino acids. It's developed in France and designed for deep skin regeneration. - HArmonyCA
In my opinion, this treatment has been a small revolution in aesthetic medicine over the past two years. It's a hybrid biostimulator combining crosslinked hyaluronic filler with calcium hydroxyapatite crystals - similar in action to Radiesse, but enhanced with hyaluronic acid. The results are consistently impressive. - Polynucleotides
Currently the hottest trend in aesthetics, popularized by Hollywood celebrities and beauty icons like Kim Kardashian, who dubbed it the "salmon sperm facial." Polynucleotides are derived from fish (trout) and rich in nucleotides - the building blocks of DNA and RNA. They rejuvenate and hydrate the skin while promoting new collagen formation. - Exosomes
Exosomes represent the most cutting-edge technology in aesthetic medicine today. I often describe them to patients as "messenger stem cells." These tiny vesicles, released by various cells, play a crucial role in intercellular communication and tissue regeneration. At Milojević Clinic, we use ASCE exosomes derived from wild rose - the most renowned brand globally. (Human-derived exosomes are prohibited in the EU.) - ABG Mesotherapy
Now, this is a true "new kid on the block"! ABG is a U.S. company producing serums that stimulate fibroblasts to produce collagen, elastin, and hyaluronic acid. Their formulas combine peptides, vitamins, amino acids, trace elements, and antioxidants, selected based on each patient's skin needs. At Milojević Clinic, we use MESO-WHARTON P199®, MESO-XANTHIN F199®,and MESOEYE C71® ABG serums. - NCTF
And finally - the "kid who's just arriving." NCTF by Fillmed are mesotherapy serums designed for skin revitalization. They combine 54 active ingredients, including vitamins, amino acids, nucleotides, trace elements, and hyaluronic acid, offering powerful skin renewal and radiance.
These ten biostimulators represent the best of modern aesthetic innovation - non-surgical, science-driven, and designed to restore the skin's natural beauty from within.
You can read more here:
Elle.hr